Women may be able to gauge their own fertility based on the age their mother went through the menopause, a Danish study has concluded.

Those whose mothers had an early menopause had far fewer eggs in their ovaries than those whose mothers had a later menopause according to the study of over 500 women aged between 20 and 40.

Lead researcher Dr Janne Bentzen said: "Our findings support the idea that the ovarian reserve is influenced by hereditary factors. However, long-term follow-up studies are required."

The team looked at two accepted methods to assess how many eggs the women had - known as their "ovarian reserve" - levels of anti-Mullerian hormone (AMH) and antral follicle count (AFC).

Women are born with all the eggs they will ever have. These are released from the ovary cyclically, usually one every month after puberty, until menopause.

The AFC and AMH give readings doctors an idea of how many yet-to-be released eggs remain in the ovary.

In the study of female healthcare workers, the researchers found both AMH and AFC declined faster in women whose mothers had menopause before the age of 45 compared to women whose mothers had a late menopause.

Average AMH levels declined by 8.6%, 6.8% and 4.2% a year in the groups of women with mothers who had early, normal or late menopauses, respectively.

A similar pattern was seen for AFC, with annual declines of 5.8%, 4.7% and 3.2% in the same groups, respectively.

Dr Valentine Akande, a consultant gynaecologist and spokesman for the British Fertility Society, said the findings were helpful, but that women should not be overly concerned if their mother did have an early menopause.

"There is a huge amount of variation among women. Some will have more eggs and some will have less. Whilst it is assumed that lower egg number is associated with more challenges at getting pregnant this study did not look at that," he said.

"Currently there is no test that can accurately predict fertility. The advice remains the same - the younger you start trying for a baby the more likely you are to be successful."

Posted 07/11/2012 by richard.hook@pavpub.com